Hughes A
Dev Med Child Neurol. 1975 Feb;17(1):111-4. doi: 10.1111/j.1469-8749.1975.tb04968.x.
There is evidence that in early embryos, mechanisms exist for the control of the movement of monovalent ions; that sodium is extruded during gastrulation and neurulation, and that in two- to three-day-old chick embryos with head abnormalities, ratios of sodium to potassium may be abnormally high. It is suggested that the origin of neural tube defects in early development may be associated with failure of control of ionic movements.
有证据表明，在早期胚胎中存在控制单价离子移动的机制；在原肠胚形成和神经胚形成过程中钠被排出，并且在头部异常的两到三天大的鸡胚胎中，钠与钾的比率可能异常高。有人提出，早期发育中神经管缺陷的起源可能与离子移动控制失败有关。
