Künzel W, Meissner C
Arch Exp Veterinarmed. 1978;32(6):823-30.
Reported in this paper are experiments conducted to compare formaldehyde, glyoxal, malondialdehyde, succindialdehyde, glutardialdehyde, adipindialdehyde, beta-propiolacton, and pyrocarbonic acid diethylester for their toxifying properties. Tetanus toxin, 1.5 million dlm/ml or 120 binding units, was used. Glutardialdehyde proved to be the most favourable compound and was followed by formaldehyde against the background of the experimental arrangement used, that is determination of concentrations for inactivation and antigenic properties of the toxoids. Glyoxal, malondialdehyde, succindialdehyde, and beta-propiolactone followed in some distance, whereas no inactivation at all was obtained from adipindialdehyde and pyrocarbonic acid diethylester.
本文报道了为比较甲醛、乙二醛、丙二醛、丁二醛、戊二醛、己二醛、β-丙内酯和焦碳酸二乙酯的毒性特性而进行的实验。使用了每毫升150万dlm或120个结合单位的破伤风毒素。在所采用的实验安排即类毒素灭活浓度和抗原特性测定的背景下，戊二醛被证明是最适宜的化合物，其次是甲醛。乙二醛、丙二醛、丁二醛和β-丙内酯在一定程度上紧随其后，而己二醛和焦碳酸二乙酯根本没有导致灭活。
