Charlton B G
Department of Psychology, University of Newcastle upon Tyne, UK.
Med Hypotheses. 2000 Jan;54(1):126-30. doi: 10.1054/mehy.1999.0986.
The malaise theory of depression constitutes a re-conceptualization and re-definition of major depressive disorder (MDD). It is proposed that the state or emotion of malaise should be considered the core symptom of depression, rather than sadness of mood. The syndrome of MDD is identified as a consequence of inappropriate sickness behavior mediated by immune activation including abnormalities in cytokines. Antidepressants are suggested to exert their specifically beneficial effects through an analgesic effect on the core dysphoric symptoms of malaise. These ideas are consistent with a substantial body of published literature and lead to a wide range of testable predictions.
抑郁症的不适理论构成了对重度抑郁症（MDD）的重新概念化和重新定义。该理论提出，应将不适的状态或情绪视为抑郁症的核心症状，而非情绪悲伤。MDD综合征被认为是由免疫激活介导的不适当疾病行为的结果，包括细胞因子异常。抗抑郁药被认为是通过对不适的核心烦躁症状产生镇痛作用而发挥其特定的有益效果。这些观点与大量已发表的文献一致，并导致了一系列可检验的预测。
