Fuller R W, Snoddy H D, Molloy B B
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):193-6.
The ability of L-5-hydroxytryptophan (L-5HTP), a serotonin precursor, to elevate plasma levels of corticosterone in rats was confirmed. Pretreatment of the rats with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenyl-propylamine hydrochloride (Lilly 110140) markedly enhanced the elevation of corticosterone levels by L-5HTP. Since Lilly 110140 is a specific inhibitor of serotonin uptake, these results support the hypothesis that L-5HTP elevates corticosterone by enhancing neurotransmission through a serotoninergic pathway influencing ACTH release.
血清素前体L-5-羟色氨酸（L-5HTP）提升大鼠血浆皮质酮水平的能力得到了证实。用3-（对-三氟甲基苯氧基）-N-甲基-3-苯基丙胺盐酸盐（礼来110140）对大鼠进行预处理，可显著增强L-5HTP对皮质酮水平的提升作用。由于礼来110140是血清素摄取的特异性抑制剂，这些结果支持了以下假说：L-5HTP通过增强影响促肾上腺皮质激素释放的血清素能途径的神经传递来提升皮质酮水平。
