紫杉烷类：最新进展。
The taxanes: an update.
作者信息
Crown J, O'Leary M
机构信息
St Vincent's University Hospital, Dublin, Ireland.
出版信息
Lancet. 2000 Apr 1;355(9210):1176-8. doi: 10.1016/S0140-6736(00)02074-2.
Abstract
The taxanes are anticancer cytotoxics that stabilise cellular microtubules. Two members, paclitaxel and docetaxel have substantial activity. One or both agents are widely accepted as evidence-based components of therapy for advanced breast, lung, and ovarian carcinomas. Paclitaxel has recently been approved in the USA for the adjuvant treatment of early stage node-positive breast carcinoma.
摘要
紫杉烷类是能使细胞微管稳定的抗癌细胞毒素。其中的两个成员，紫杉醇和多西他赛具有显著活性。这两种药物中的一种或两种已被广泛认可为晚期乳腺癌、肺癌和卵巢癌循证治疗的组成部分。紫杉醇最近在美国已被批准用于早期淋巴结阳性乳腺癌的辅助治疗。
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