Jacob R J, Lebowitz J, Printz M P
Nucleic Acids Res. 1974 Apr;1(4):549-58. doi: 10.1093/nar/1.4.549.
Kinetic analysis of the early, fast reaction of superhelical DNA with formaldehyde reveals that this region or regions is 56% "single strand like" in character. Hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form I and form II molecules, but is due to unpaired or weakly hydrogen bonded, localized region(s) of the form I allomorph of circular DNA.
超螺旋DNA与甲醛早期快速反应的动力学分析表明,该区域或这些区域在性质上56%是“单链样”的。氢-氚交换研究以及其他考虑因素表明,该反应并非由于I型和II型分子构象运动性的差异,而是由于环状DNA I型同素异形体未配对或氢键较弱的局部区域。