静脉注射碘化造影剂碘普罗胺后极低出生体重儿的甲状腺功能
Thyroid function in very low birthweight infants after intravenous administration of the iodinated contrast medium iopromide.
作者信息
Dembinski J, Arpe V, Kroll M, Hieronimi G, Bartmann P
机构信息
Department of Neonatology, Children's University Clinic Bonn, Germany.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F215-7. doi: 10.1136/fn.82.3.f215.
BACKGROUND
Thyroid function disorders have often been observed in preterm infants after intravenous administration of iodinated contrast medium. The effect on thyroid function depends on the dosage, but the choice of the contrast medium may be equally important, as there are appreciable pharmacological differences between them.
METHOD
Thyroid function was analysed in 20 very low birthweight infants of gestational age less than 30 weeks after injection of iopromide, a monomeric non-ionic iodinated contrast medium. Levels of free thyroxine and thyroid stimulating hormone were compared with those in 26 control infants.
RESULTS
Free thyroxine levels in all study infants ranged from 9.0 to 25.7 pmol/l (days 14-21) and 9.0 to 23.2 pmol/l (days 35-49), and thyroid stimulating hormone levels ranged from 0.13 to 0.26 mU/l (days 14-21) and 0.26 to 11.11 mU/l (days 35-49). These levels were not altered after injection of iopromide.
CONCLUSION
The risk of transient hypothyroidism or hyperthyrotropinaemia may be reduced with the use of iopromide compared with other contrast media.
背景
静脉注射碘化造影剂后，早产婴儿中常观察到甲状腺功能紊乱。对甲状腺功能的影响取决于剂量，但造影剂的选择可能同样重要，因为它们之间存在明显的药理学差异。
方法
对20例胎龄小于30周的极低出生体重婴儿注射单体非离子碘化造影剂碘普罗胺后进行甲状腺功能分析。将游离甲状腺素和促甲状腺激素水平与26例对照婴儿的水平进行比较。
结果
所有研究婴儿的游离甲状腺素水平在第14 - 21天为9.0至25.7 pmol/l，在第35 - 49天为9.0至23.2 pmol/l；促甲状腺激素水平在第14 - 21天为0.13至0.26 mU/l，在第35 - 49天为0.26至11.11 mU/l。注射碘普罗胺后这些水平未发生改变。
结论
与其他造影剂相比，使用碘普罗胺可能会降低短暂性甲状腺功能减退或促甲状腺激素血症的风险。
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