Dhenain M, Michot J L, Privat N, Picq J L, Boller F, Duyckaerts C, Volk A
Institut National de la Santé et de la Recherche Médicale (INSERM) U 350, Institut Curie, 91405 Orsay, Cedex, France.
Neurobiol Aging. 2000 Jan-Feb;21(1):81-8. doi: 10.1016/s0197-4580(00)00098-1.
We assessed cerebral atrophy in mouse lemur primates (Microcebus murinus) by estimating CSF volume in their brains from 4.7 Tesla T2-weighted magnetic resonance images. Thirty animals aged from 1 to 10.3 years were imaged, 14 of them were followed for up to 2 years. Seven of these animals were examined for neuropathology. In 12 out of 17 animals older than 3.5 years, CSF volumes were increased. A subgroup of six animals had severe atrophy of the temporal lobe. Another subgroup of five animals displayed diffuse atrophy in addition to the temporal atrophy. One animal had a dilation of the external part of the temporal horn of the lateral ventricle in addition to the temporal atrophy. The three animals with diffuse atrophy that could be studied for neuropathology had diffuse cerebral amyloid deposits detected by immunocytochemistry. The other animals did not display amyloid deposits. Relations between the different types of atrophy as well as their causes will have to be assessed in future studies.
我们通过从4.7特斯拉T2加权磁共振图像估计小鼠狐猴灵长类动物（小嘴狐猴）大脑中的脑脊液体积，来评估其脑萎缩情况。对30只年龄在1至10.3岁的动物进行了成像，其中14只动物被跟踪观察长达2年。对其中7只动物进行了神经病理学检查。在17只年龄超过3.5岁的动物中，有12只脑脊液体积增加。一个由6只动物组成的亚组出现了严重的颞叶萎缩。另一个由5只动物组成的亚组除了颞叶萎缩外还表现出弥漫性萎缩。1只动物除了颞叶萎缩外，侧脑室颞角外部还出现了扩张。对3只可进行神经病理学研究的弥漫性萎缩动物进行免疫细胞化学检测，发现有弥漫性脑淀粉样蛋白沉积。其他动物未显示淀粉样蛋白沉积。不同类型萎缩之间的关系及其原因将有待在未来的研究中进行评估。
