Schmidt P, Kopsa H, Zazgornik J
Dtsch Med Wochenschr. 1975 Jun 13;100(24):1335-7. doi: 10.1055/s-0028-1106382.
Severe acute renal failure developed in a patient with systemic lupus erythematosus which was characterized by typical skin rash, polyserositis, haemolytic anaemia and liver damage. Serological examination revealed anti-DNA antibodies in high concentrations, positive Coombs' test, excessive elevation of serum-IgG with markedly depressed serum complement fractions (C3, C4). Acute lupus nephritis led to prolonged oliguria and anuria requiring regular dialysis over almost five months. Immuno-suppressive treatment with cortisone and azathioprine finally reversed the renal failure: BUN returned to 33 mg/ 100 ml, with a plasma creatinine of 1.8 mg per 100 ml.
一名系统性红斑狼疮患者出现严重急性肾衰竭,其特征为典型皮疹、多浆膜炎、溶血性贫血和肝损伤。血清学检查显示高浓度抗DNA抗体、库姆斯试验阳性、血清IgG过度升高且血清补体成分(C3、C4)明显降低。急性狼疮性肾炎导致长时间少尿和无尿,几乎五个月需要定期透析。使用可的松和硫唑嘌呤进行免疫抑制治疗最终使肾衰竭得到逆转:尿素氮恢复到33mg/100ml,血浆肌酐为1.8mg/100ml。