Padovan C S, Sostak P, Straube A
Neurologische Klinik, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Nervenarzt. 2000 Apr;71(4):249-58. doi: 10.1007/s001150050554.
Following organ transplantation, 30-60% of patients develop neurologic complications which can be classified as pre-existing deficits due to the underlying disease, complications during surgery, metabolic encephalopathies, neurotoxicity of immunosuppressant agents, opportunistic CNS infections, and secondary malignomas as indirect side effects of immunosuppression. While encephalopathies, seizures, or CNS infection can occur in all types of transplantation, some specific neurological complications exist for different types of organ transplantation. In this review, the clinical symptoms and treatment of both the common neurological complications as well as the particular neurological syndromes after liver, heart, and bone marrow transplantation are discussed.
器官移植后，30%至60%的患者会出现神经并发症，这些并发症可分为由于基础疾病导致的既往缺陷、手术期间的并发症、代谢性脑病、免疫抑制剂的神经毒性、机会性中枢神经系统感染以及作为免疫抑制间接副作用的继发性恶性肿瘤。虽然脑病、癫痫发作或中枢神经系统感染可发生于所有类型的移植中，但不同类型的器官移植存在一些特定的神经并发症。在本综述中，将讨论肝移植、心脏移植和骨髓移植后常见神经并发症以及特殊神经综合征的临床症状和治疗方法。
