Wessel I, Mogielski K, Heieck B
Neurologische Klinik, Johanna-Etienne-Krankenhaus, Neuss.
Nervenarzt. 2000 Apr;71(4):295-8. doi: 10.1007/s001150050560.
Paraneoplastic neurological syndromes are rare diseases that occur in relation to cancer. Supporting the hypothesis of an autoimmune mechanism, specific antineuronal antibodies have sometimes been detected. The current possibilities for treatment are limited. A female patient, aged 57, suffering from a breast cancer, developed a severe paraneoplastic cerebellar syndrome and limbic encephalitis within a few weeks. It is possible that the impressive partial remission that occurred during the ensuing 6 months was not due to therapy. Although the patient was still bound to a wheelchair, discharge from hospital was possible because she was still able to perform daily tasks by herself. A recurrence of the cerebellar symptoms with mild alterations of mental status occurred 2 months later but again showed a good remission.
副肿瘤性神经系统综合征是与癌症相关的罕见疾病。支持自身免疫机制假说的是，有时会检测到特异性抗神经元抗体。目前的治疗可能性有限。一名57岁的女性乳腺癌患者在几周内出现了严重的副肿瘤性小脑综合征和边缘叶脑炎。随后6个月内出现的显著部分缓解可能并非由于治疗。尽管患者仍需依靠轮椅，但由于她仍能自行完成日常任务，所以可以出院。2个月后小脑症状复发，伴有轻度精神状态改变，但再次显示出良好的缓解。
