Kramer M S
Faculty of Medicine, McGill University, 1020 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A2.
Cochrane Database Syst Rev. 2000;1996(2):CD000131. doi: 10.1002/14651858.CD000131.
To assess the effects of prescribing an antigen avoidance diet to lactating mothers of infants with atopic eczema on the severity of the eczema.
The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group.
All acceptably controlled comparisons of maternal antigen avoidance prescribed to lactating mothers of infants with atopic eczema, regardless of the degree of antigen avoidance (number of foods eliminated from the diet) or its duration.
Data were extracted by the author from published reports, and supplemented by additional information from trialists contacted by the author.
One trial involving 17 women was included. Based on this single small trial, maternal antigen avoidance was associated with a nonsignificant reduction in eczema severity.
REVIEWER'S CONCLUSIONS: The unimpressive results of this single trial should be interpreted with caution both because of its small size (n=17) and because the trial compared exposure to cow milk and egg with exposure to soya milk (soya can itself be allergenic). Maternal reports of changes in the severity of their breast-fed infants' eczema following ingestion of certain foods should be pursued by performing multiple (preferably double-blinded) challenges and dechallenges with the suspected foods.
评估为患有特应性湿疹婴儿的哺乳期母亲开具抗原回避饮食对湿疹严重程度的影响。
Cochrane妊娠与分娩小组维护和更新的临床试验注册库。
所有对患有特应性湿疹婴儿的哺乳期母亲开具的母亲抗原回避进行的可接受对照比较，无论抗原回避程度（从饮食中排除的食物数量）或其持续时间如何。
作者从已发表的报告中提取数据，并通过与作者联系的试验者提供的其他信息进行补充。
纳入一项涉及17名女性的试验。基于这一单一的小型试验，母亲抗原回避与湿疹严重程度的非显著降低相关。
由于该试验规模较小（n = 17），且该试验将接触牛奶和鸡蛋与接触豆奶（豆奶本身可能具有致敏性）进行了比较，因此应谨慎解释这一单一试验的平淡结果。应通过对疑似食物进行多次（最好是双盲）激发和再激发试验，来研究母亲报告的母乳喂养婴儿摄入某些食物后湿疹严重程度的变化。
