Kenyon S, Boulvain M
ORACLE Clinical Co-ordinating Centre, Leicester Royal Infirmary, Department of Obstetrics, Clinical Sciences Building, PO Box 65, Leicester, UK, LE2 7ZR.
Cochrane Database Syst Rev. 2000(2):CD001058. doi: 10.1002/14651858.CD001058.
The aim of the review was to evaluate the effectiveness and the immediate and long-term safety of the effects of administering antibiotics to women with preterm prelabour rupture of membranes on maternal infectious morbidity, fetal and neonatal morbidity and mortality, and longer term childhood development.
All randomized trials identified using the search strategy described by the Cochrane Pregnancy and Childbirth Group.
All trials which reported clinically relevant outcomes (as opposed to laboratory data) were included.
Data were extracted from each report without any blinding of either the results or the treatments which women received. Unpublished data were sought from a number of authors.
Antibiotic treatment following pPROM is effective at prolonging pregnancy and reducing maternal and neonatal infectious morbidity. There is no statisically proven benefit that their use improves neonatal mortality and morbidity in the short or long term.
REVIEWER'S CONCLUSIONS: There are insufficient data to recommend routine prescription of antibiotics in this clinical situation. Research into this area should continue.
本综述旨在评估对胎膜早破的早产妇女使用抗生素对孕产妇感染性发病率、胎儿和新生儿发病率及死亡率以及儿童长期发育的有效性、近期和远期安全性。
使用Cochrane妊娠与分娩小组描述的检索策略确定所有随机试验。
纳入所有报告临床相关结局（而非实验室数据）的试验。
从每份报告中提取数据，不对结果或妇女接受的治疗进行任何盲法处理。向多位作者索取未发表的数据。
胎膜早破后使用抗生素可有效延长孕周并降低孕产妇和新生儿感染性发病率。没有统计学证据表明使用抗生素能在短期或长期改善新生儿死亡率和发病率。
在这种临床情况下，没有足够的数据推荐常规使用抗生素。该领域的研究应继续进行。
