Ishikawa Y
Division of Biology, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba, Japan.
Bioessays. 2000 May;22(5):487-95. doi: 10.1002/(SICI)1521-1878(200005)22:5<487::AID-BIES11>3.0.CO;2-8.
Several teleosts, such as the zebrafish and the medakafish or medaka (Oryzias latipes), are used as vertebrate model systems in various fields of biology. The medaka is suitable for use in genomic studies because of its small genome size. Moreover, our recent results of small-scale mutagenesis in the medaka indicate that it is possible to identify mutations, the phenotypes of which could not be found in zebrafish mutants obtained by large-scale mutagenesis. An example is Oot (One-sided optic tectum), a maternal-effect mutation. In the Oot phenotype, bilateral symmetry is broken in the optic tectum in the early developmental stages, and either the left or right morphology is duplicated on both sides. Medaka inbred strains can be produced and used to study quantitative traits in vertebrate development. Data presented support the use of medaka as another important fish model for the study of vertebrate developmental genetics.
几种硬骨鱼，如斑马鱼和青鳉（Oryzias latipes），在生物学的各个领域被用作脊椎动物模型系统。青鳉因其基因组较小而适合用于基因组研究。此外，我们最近在青鳉中进行的小规模诱变结果表明，有可能识别出在通过大规模诱变获得的斑马鱼突变体中未发现其表型的突变。一个例子是Oot（单侧视顶盖），一种母体效应突变。在Oot表型中，双侧对称性在早期发育阶段的视顶盖中被打破，并且左右形态中的一方在两侧重复出现。可以培育青鳉近交系并用于研究脊椎动物发育中的数量性状。所提供的数据支持将青鳉用作研究脊椎动物发育遗传学的另一种重要鱼类模型。
