Jurkiewicz A, do Carmo L G, Yomura M H, Jurkiewicz N H
Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brasil.
Acta Physiol Pharmacol Ther Latinoam. 1999;49(4):210-4.
The contractile effect of serotonin was studied in rat vas deferens, in comparison with that of noradrenaline and tyramine, after reserpine treatment, surgical denervation, and transplantation to the colon. In reserpinized animals the effect of 5HT resembled that of tyramine, since it was strikingly reduced, in spite of a small residual effect, showing that in normal preparations the effects of 5HT and tyramine are predominantly due to the release of endogenous noradrenaline. However, in denervated or transplanted vas deferens, in which the effect of tyramine is also abolished, the effect of 5HT was potentiated. It is suggested that after chronic, long lasting depletion of endogenous noradrenaline, there are alternate mechanisms that are generated to improve the contractile effect of 5HT, but not of tyramine. The nature of these mechanisms is still unknown.
在利血平处理、手术去神经支配以及移植至结肠后，研究了5-羟色胺（血清素）在大鼠输精管中的收缩作用，并与去甲肾上腺素和酪胺的收缩作用进行比较。在利血平化的动物中，5-羟色胺的作用类似于酪胺，因为尽管有小的残余作用，但其作用显著降低，这表明在正常制剂中，5-羟色胺和酪胺的作用主要是由于内源性去甲肾上腺素的释放。然而，在去神经支配或移植的输精管中，酪胺的作用也被消除，5-羟色胺的作用却增强了。有人提出，在内源性去甲肾上腺素长期慢性耗竭后，会产生替代机制来增强5-羟色胺的收缩作用，但不会增强酪胺的收缩作用。这些机制的性质仍然未知。
