Ma L, Yao M, Maas R L
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Semin Reprod Endocrinol. 1999;17(3):205-16. doi: 10.1055/s-2007-1016228.
Implantation involves complex molecular interactions between implanting blastocysts and the hormonally primed uterus. Gene targeting allows the generation of mice lacking a specific gene or genes and has proved to be of considerable value when combined with classical physiology in understanding many biological questions, such as the process of implantation. In this article, we review genes that have been demonstrated by gene targeting in mice to be required in the uterus for implantation. In particular, we focus on a specific class of developmental control genes, the mammalian Hox genes, and their role in this process. Lastly, we attempt to synthesize current knowledge about the genetic control of implantation and to build a working genetic model for the implantation pathway.
着床涉及植入的囊胚与经激素预处理的子宫之间复杂的分子相互作用。基因靶向技术可产生缺乏特定一个或多个基因的小鼠，并且在与经典生理学相结合以理解许多生物学问题（如着床过程）时已证明具有相当大的价值。在本文中，我们综述了通过小鼠基因靶向技术已证实在子宫着床过程中必需的基因。特别地，我们聚焦于一类特定的发育控制基因——哺乳动物Hox基因，及其在这一过程中的作用。最后，我们试图综合目前关于着床遗传控制的知识，并构建一个关于着床途径的有效遗传模型。
