Tamer S K
Department of Neurosciences, JLN Hospital and Research Centre, Bhilai, MP.
Indian J Pediatr. 1999 Nov-Dec;66(6):877-86. doi: 10.1007/BF02723860.
Cognitive performance in an epileptic child has been a difficult issue to predict in day-to-day clinical practice. Several observations made in early and later part of this century do not provide uniform and convincing answer to this issue. Recent trends in research however, have identified certain variables that are shown to be associated with cognitive decline in epileptic children. Together with associated behavioural problems, the resultant school difficulty is the essence of this concern for the parents. The variables related to cognitive deterioration as identified by several studies include underlying brain pathology (symptomatic epilepsy), early age of onset of seizure, severity and intractability of seizure, repeated head trauma, an episode of status epilepticus, presence of interictal subclinical EEG discharge, adverse psychosocial factor and antiepileptic drug (AED). Association of these variables in a given case cannot only predict adverse cognition outcome but also a preventive management package can be planned aiming at avoiding or minimizing these high risk variables.
在日常临床实践中,预测癫痫儿童的认知表现一直是个难题。本世纪早期和后期的一些观察结果并未对这一问题给出统一且令人信服的答案。然而,最近的研究趋势已经确定了某些变量,这些变量被证明与癫痫儿童的认知衰退有关。连同相关的行为问题一起,由此导致的学业困难是家长们关注的核心问题。多项研究确定的与认知恶化相关的变量包括潜在的脑部病变(症状性癫痫)、癫痫发作的早期年龄、癫痫发作的严重程度和难治性、反复头部外伤、癫痫持续状态发作、发作间期亚临床脑电图放电的存在、不良心理社会因素以及抗癫痫药物(AED)。在特定病例中,这些变量的关联不仅可以预测不良的认知结果,还可以制定预防性管理方案,旨在避免或最小化这些高风险变量。