皮下硬结的放射生物学深度。

Radiobiological depth of subcutaneous induration.

作者信息

Nuutinen J, Väänänen A, Lahtinen T, Turunen M, Remes S, Alanen E

机构信息

Department of Oncology, Kuopio University Hospital, FIN-70210, Kuopio, Finland.

出版信息

Radiother Oncol. 2000 May;55(2):187-90. doi: 10.1016/s0167-8140(99)00147-4.

DOI:10.1016/s0167-8140(99)00147-4

PMID:10799731

Abstract

The incidence of subcutaneous induration in 23 breast cancer patients with postmastectomy radiotherapy was investigated. The patients were treated with three different radiotherapy schedules 7. 9-9.8 years ago. The incidence was correlated with the biological effective dose (BED) at different depths from the skin surface and a best fit was obtained using an alpha/beta ratio of 2 Gy. The most representative depth at which to assess dose for subcutaneous induration was 2 mm which is near the subcutaneous fat/dermis interface.

摘要

对23例接受乳房切除术后放疗的乳腺癌患者皮下硬结的发生率进行了调查。这些患者于7.9 - 9.8年前接受了三种不同的放疗方案治疗。该发生率与皮肤表面不同深度处的生物等效剂量（BED）相关，且使用2 Gy的α/β比值获得了最佳拟合。评估皮下硬结剂量的最具代表性深度为2 mm，该深度靠近皮下脂肪/真皮界面。