Adams P R
Br J Pharmacol. 1975 Feb;53(2):308-10. doi: 10.1111/j.1476-5381.1975.tb07364.x.
The effect of rapid hyperpolarization on acetylcholine- or carbachol-induced currents was studied at voltage clamped frog endplates. Following a hyperpolarizing step the agonist-induced conductance increased approximately exponentially to a new level. The rate constant for this process was smaller during hyperpolarization or lowered temperature, and was also smaller for acetylcholine than for carbachol. The results are interpreted in terms of a potential-dependent conformational change of the receptor.
在电压钳制的青蛙终板上研究了快速超极化对乙酰胆碱或卡巴胆碱诱导电流的影响。在超极化步骤之后,激动剂诱导的电导近似呈指数增加至新水平。该过程的速率常数在超极化期间或温度降低时较小,并且对于乙酰胆碱而言也比对卡巴胆碱小。结果根据受体的电位依赖性构象变化进行解释。