用7,12-二甲基苯并[a]蒽及其弱致癌性5-氟类似物处理的叙利亚仓鼠胚胎细胞中的DNA修复
DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog.
作者信息
D'Ambrosio S M, Daniel F B, Hart R W, Cazer F D, Witiak D T
出版信息
Cancer Lett. 1979 Apr;6(4-5):255-61. doi: 10.1016/s0304-3835(79)80043-9.
PMID:108012
Abstract
The postreplication repair capacity of Syrian hamster embryo cells in culture was determined after treatment with the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) and its weakly carcinogenic analog 5-F-DMBA. The size and amount of daughter DNA sedimenting as high-molecular-weight DNA were found to be less in the DMBA treated cells than in the 5-F-DMBA-treated cells. This difference probably depends upon the types of adducts entering DNA replication.
摘要
在用强效致癌物7,12-二甲基苯并[a]蒽（DMBA）及其弱致癌类似物5-F-DMBA处理后，测定了培养的叙利亚仓鼠胚胎细胞的复制后修复能力。结果发现，与5-F-DMBA处理的细胞相比，DMBA处理的细胞中沉降为高分子量DNA的子代DNA的大小和数量更少。这种差异可能取决于进入DNA复制的加合物类型。
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