Wickner R B, Taylor K L, Edskes H K, Maddelein M L
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, 20892-0830, USA.
Curr Biol. 2000 May 4;10(9):R335-7. doi: 10.1016/s0960-9822(00)00460-7.
Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
在酵母中已鉴定出自我传播的异常蛋白质——朊病毒；这些蛋白质中富含天冬酰胺/谷氨酰胺的“朊病毒结构域”可使相连的功能结构域失活；新的朊病毒结构域和报告基因已被用于制造“合成朊病毒”，从而发现了新的天然朊病毒。
