The role of Ran in nuclear function.

There have been three major advances in the understanding of the Ran pathway during the past two years: first, a general model for Ran's function in nuclear transport has been proposed and extensively tested. Second, crystal structures for many proteins that regulate or interact with Ran have been reported, which provide molecular details of how Ran works. Third, it has been documented that Ran regulates mitotic spindle assembly in a transport-independent fashion.