Azuma Y, Dasso M
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5431, USA.
Curr Opin Cell Biol. 2000 Jun;12(3):302-7. doi: 10.1016/s0955-0674(00)00093-4.
There have been three major advances in the understanding of the Ran pathway during the past two years: first, a general model for Ran's function in nuclear transport has been proposed and extensively tested. Second, crystal structures for many proteins that regulate or interact with Ran have been reported, which provide molecular details of how Ran works. Third, it has been documented that Ran regulates mitotic spindle assembly in a transport-independent fashion.
在过去两年里，人们对Ran途径的理解取得了三项重大进展：第一，提出了Ran在核运输中功能的通用模型并进行了广泛测试。第二，已报道了许多调节Ran或与Ran相互作用的蛋白质的晶体结构，这提供了Ran如何发挥作用的分子细节。第三，已证明Ran以一种不依赖运输的方式调节有丝分裂纺锤体组装。
