Gupta S V, Khosla P
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA.
J Nutr. 2000 May;130(5):1217-24. doi: 10.1093/jn/130.5.1217.
The effects on plasma lipoprotein metabolism of replacing pork fat (PF) with chicken fat (CF) (formulated as part of currently recommended prudent diets) was evaluated in 10 male cynomolgus monkeys. Monkeys were rotated through three dietary periods, (each of 10-wk duration), during which total cholesterol (TC), triacylglycerol (TG) and HDL-cholesterol (HDL-C) were measured (7, 8 and 9 wk) and in vivo lipoprotein metabolism evaluated (after 9 wk). Initially, all monkeys were fed a high-fat, high-cholesterol reference diet [38% of energy (en) from fat, 18%en saturated fatty acids (SFA), 10%en monounsaturated fatty acids (MUFA), 10%en polyunsaturated fatty acids (PUFA), 0.045 mg cholesterol/kJ diet]. Subsequently, monkeys were rotated through two test diets (30%en fat, SFA/MUFA/PUFA 1:1:1, 0.004-0.005 mg cholesterol/kJ diet), in which 80% of the fat was either PF or CF, with the remaining 20% derived from high-linoleic safflower oil. There was no significant difference between the two test diets for TG, TC, nonHDL-C, HDL-C or the ratio of TC/HDL-C. Lipoprotein composition, LDL apolipoprotein B pool size, fractional catabolic rate and transport rate were also not significantly different when monkeys consumed the two test diets. These data suggest that when incorporated into diets following current guidelines and containing adequate PUFA ( approximately 7-9%en), PF and CF similarly affect plasma lipids.
在10只雄性食蟹猴中评估了用鸡脂肪（CF）替代猪脂肪（PF）（作为当前推荐的谨慎饮食的一部分）对血浆脂蛋白代谢的影响。猴子经历三个饮食阶段（每个阶段持续10周），在此期间测量总胆固醇（TC）、三酰甘油（TG）和高密度脂蛋白胆固醇（HDL-C）（在第7、8和9周），并在9周后评估体内脂蛋白代谢。最初，所有猴子喂食高脂肪、高胆固醇参考饮食[38%的能量（en）来自脂肪，18%en饱和脂肪酸（SFA），10%en单不饱和脂肪酸（MUFA），10%en多不饱和脂肪酸（PUFA），0.045 mg胆固醇/kJ饮食]。随后，猴子轮流食用两种试验饮食（30%en脂肪，SFA/MUFA/PUFA 1:1:1，0.004 - 0.005 mg胆固醇/kJ饮食），其中80%的脂肪要么是PF要么是CF，其余20%来自高亚油酸红花油。两种试验饮食在TG、TC、非HDL-C、HDL-C或TC/HDL-C比值方面没有显著差异。当猴子食用两种试验饮食时，脂蛋白组成、低密度脂蛋白载脂蛋白B池大小、分解代谢率分数和转运率也没有显著差异。这些数据表明，当按照当前指南纳入饮食并含有足够的PUFA（约7 - 9%en）时，PF和CF对血浆脂质的影响相似。
