Offer I, Ashkenazi S, Livni G, Shalit I
Department of Pediatrics, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
Isr Med Assoc J. 2000 Feb;2(2):108-10.
Bronchiolitis caused by respiratory syncytial virus is one of the major causes of hospitalization in young children, especially during the winter. Recent evidence has shown that pharmacological treatment, especially nebulized epinephrine, in addition to the traditional supportive treatment, can alleviate symptoms and shorten hospitalization, but this approach is not yet widespread.
To determine whether the management of bronchiolitis in Israel is moving toward a stronger emphasis on pharmacological care.
A questionnaire on the diagnosis and management of bronchiolitis was completed by 27 heads of pediatric departments throughout Israel. The questionnaire dealt with the frequency of usage of diagnostic and selected therapeutic procedures.
Chest X-ray and arterial blood gases are commonly used as a diagnostic aid in more than 75% of the departments, and antibiotics are prescribed routinely in 24%. Corticosteroids are still in use: 48% use systemic steroids, and 19% nebulized steroids. Nebulized epinephrine is used in 22% of the departments, while nebulized beta-agonists are used frequently in two-thirds of the departments.
Despite convincing data that beta-agonists and steroids have no positive effect on the outcome of bronchiolitis on the one hand, and that nebulized epinephrine has advantages in children on the other, we found significant use of the former two agents and sparse use of the latter. Greater awareness is needed among pediatricians, and measures should be introduced to incorporate the new recommendations, with further study of the effect of the old and new drugs on bronchiolitis.
呼吸道合胞病毒引起的细支气管炎是幼儿住院的主要原因之一,尤其是在冬季。最近的证据表明,除传统的支持性治疗外,药物治疗,尤其是雾化肾上腺素,可缓解症状并缩短住院时间,但这种方法尚未广泛应用。
确定以色列细支气管炎的管理是否更加强调药物治疗。
以色列27位儿科主任完成了一份关于细支气管炎诊断和管理的问卷。问卷涉及诊断和选定治疗程序的使用频率。
超过75%的科室通常将胸部X光和动脉血气作为诊断辅助手段,24%的科室常规使用抗生素。仍在使用皮质类固醇:48%使用全身性类固醇,19%使用雾化类固醇。22%的科室使用雾化肾上腺素,而三分之二的科室经常使用雾化β受体激动剂。
尽管有令人信服的数据表明,一方面β受体激动剂和类固醇对细支气管炎的预后没有积极影响,另一方面雾化肾上腺素对儿童有优势,但我们发现前两种药物的使用量很大,而后者的使用量很少。儿科医生需要提高认识,并应采取措施纳入新的建议,同时进一步研究新旧药物对细支气管炎的影响。