犬上皮性皮肤肿瘤的细胞角蛋白谱

A cytokeratin profile of canine epithelial skin tumours.

作者信息

Walter J

机构信息

Institut für Veterinär-Pathologie der Freie Universität Berlin, Strasse 518 Nr. 15, Berlin, D-14163, Germany.

出版信息

J Comp Pathol. 2000 May;122(4):278-87. doi: 10.1053/jcpa.1999.0372.

DOI:10.1053/jcpa.1999.0372

PMID:10805981

Abstract

The reactions of a number of epithelial skin tumours in dogs to a panel of monoclonal antibodies against different human cytokeratins (CKs) were examined immunohistochemically, the purpose being to detect a specific CK profile. CK 6 was present in all epithelial skin tumours with the exception of pilomatrixoma. CK 14 was found in basal cell-derived neoplasias and in sebaceous and perianal gland tumours. CK 10/11 was restricted to spinous cell-derived tumours and CK 8/18 was limited to sweat gland tumours.

摘要

采用免疫组织化学方法检测了犬的多种上皮性皮肤肿瘤对一组针对不同人细胞角蛋白（CKs）的单克隆抗体的反应，目的是检测特定的CK谱。除毛母质瘤外，所有上皮性皮肤肿瘤中均存在CK 6。CK 14见于基底细胞来源的肿瘤以及皮脂腺和肛周腺肿瘤。CK 10/11仅限于棘状细胞来源的肿瘤，CK 8/18仅限于汗腺肿瘤。