Kok Mun Keong, Chambers James K, Dohata Atsushi, Uchida Kazuyuki, Nishimura Ryohei, Nakayama Hiroyuki
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2017 Jun 10;79(6):984-987. doi: 10.1292/jvms.17-0178. Epub 2017 May 1.
A 10-year-old mixed breed dog was presented with a 0.8 cm diameter mass below the left eye region. The mass was surgically removed and processed for histopathological examination. Microscopically, tumor cells proliferated in small lobules, nests and cords, and the tumor parenchyma was separated by desmoplastic stroma. Majority of the tumor cells were periodic acid-Schiff (PAS)-positive, and the desmoplastic stroma was densely collagenous and mucinous. Immunohistochemical results showed that the tumor cells were diffusely positive for cytokeratin 15, cytokeratin 19 and CD 34, while cytokeratin 8 reactivity was limited to the tumor cells proliferating in cords. Few tumor cells were positive for nestin. Based on the histopathological findings, the tumor was diagnosed as desmoplastic tricholemmoma.
一只10岁的混血犬因左眼下方出现一个直径0.8厘米的肿块前来就诊。该肿块经手术切除并进行组织病理学检查。显微镜下，肿瘤细胞呈小叶状、巢状和条索状增殖，肿瘤实质被促纤维增生性间质分隔。大多数肿瘤细胞呈过碘酸希夫（PAS）阳性，促纤维增生性间质富含胶原且呈黏液样。免疫组化结果显示，肿瘤细胞对细胞角蛋白15、细胞角蛋白19和CD 34呈弥漫性阳性，而细胞角蛋白8的反应性仅限于呈条索状增殖的肿瘤细胞。少数肿瘤细胞对巢蛋白呈阳性。根据组织病理学检查结果，该肿瘤被诊断为促纤维增生性外毛根鞘瘤。
