Piquard F, Geny B, Hardy H, Chakfe N, Mettauer B, Charloux A, Lampert E, Lonsdorfer J
Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Faculté de Médecine, and Service d'Explorations Fonctionnelles Physiologiques, Hôpitaux Universitaires, Strasbourg, France.
J Heart Lung Transplant. 2000 May;19(5):507-9. doi: 10.1016/s1053-2498(00)00092-9.
Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined.
Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients.
No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation.
环孢素可导致心房利钠肽（ANP）水平正常的受试者出现每日肾脏低灌注，但它在ANP升高的心脏移植患者中的急性效应仍有待确定。
对6例心脏移植患者给予环孢素后7小时内监测环孢素血症和肌酐清除率。
心脏移植后未观察到环孢素引起的肌酐清除率急性下降。这些数据表明，维持性环孢素剂量的肾毒性可能比怀疑的要小，且升高的ANP可能在心脏移植后期保护肾功能。
