Arai Y, Ackerley C A, Becker L E
Department of Clinical Laboratory, Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan.
Ultrastruct Pathol. 2000 Mar-Apr;24(2):93-8. doi: 10.1080/01913120050118567.
The expression of tuberin in neurosurgically resected gangliogliomas was investigated. Neither neoplastic astrocytes nor abnormal, multipolar large neurons showed immunoreactivity for tuberin. The reduced immuno-histochemical staining for tuberin was consistent with the reduction observed in Western blot analysis. Eosinophilic granular bodies and Rosenthal fibers were strongly immunoreactive for tuberin. The accumulation of tuberin in astrocytes with intracellular degenerative changes suggests increased expression in reactive cells, and perhaps a broader role for tuberin in central nervous system disease.
研究了神经外科手术切除的节细胞胶质瘤中结节性硬化蛋白的表达情况。肿瘤性星形胶质细胞和异常的多极大型神经元均未显示出结节性硬化蛋白的免疫反应性。结节性硬化蛋白免疫组织化学染色减少与蛋白质印迹分析中观察到的减少一致。嗜酸性颗粒小体和罗森塔尔纤维对结节性硬化蛋白呈强免疫反应性。结节性硬化蛋白在伴有细胞内退行性改变的星形胶质细胞中的积累表明其在反应性细胞中表达增加，并且结节性硬化蛋白在中枢神经系统疾病中可能具有更广泛的作用。
