Chuangsuwanich A, Osathalert V, Muangsombut S
Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2000 Apr;83(4):439-44.
An open clinical trial was conducted to assess the effect of self-adhesive silicone gel sheet (SASGS) for the treatment of hypertrophic scars and keloids in Thai people. Patients were instructed to apply the SASGS to the scars as long as possible, but not less than 12 hours per day for at least 8 weeks. The subjective results of the treatment were evaluated by the patients. The scars were evaluated for color, height, weight before and after treatment at 4 and 8 weeks. Eighteen patients with 18 hypertrophic scars or keloids were recruited into the study. Their ages ranged from 6 to 33 years (mean 21 years). The average duration of the scars was 5.7 years. Twelve patients (66.67%) stated good results. All of the 18 patients wanted to continue the treatment with SASGS. Heights of the scars were reduced in 12 lesions (66.67%) after treatment for 8 weeks (P = 0.058). Weights of the lesions were decreased in 10 lesions (55.55%) but were not statistically different (P = 0.090). Seven lesions (36.84%) were improved in color. Two patients (11.11%) developed erythematous rash around the lesions which subsided after withdrawal of the treatment. The long term follow-up for the recurrence and the mechanism of action of this treatment should be studied further.
开展了一项开放性临床试验，以评估自粘性硅胶片（SASGS）对泰国人增生性瘢痕和瘢痕疙瘩的治疗效果。指导患者尽可能长时间地将SASGS贴于瘢痕处，但每天不少于12小时，至少持续8周。由患者对治疗的主观结果进行评估。在治疗前以及治疗4周和8周后，对瘢痕的颜色、高度和重量进行评估。18例患有增生性瘢痕或瘢痕疙瘩的患者被纳入该研究。他们的年龄在6至33岁之间（平均21岁）。瘢痕的平均病程为5.7年。12例患者（66.67%）表示效果良好。所有18例患者都希望继续使用SASGS进行治疗。治疗8周后，12处瘢痕（66.67%）的高度降低（P = 0.058）。10处瘢痕（55.55%）的重量减轻，但差异无统计学意义（P = 0.090）。7处瘢痕（36.84%）的颜色有所改善。2例患者（11.11%）在瘢痕周围出现红斑疹，停药后消退。该治疗的复发情况及作用机制的长期随访研究有待进一步开展。
