幽门螺杆菌成熟空泡毒素N端的自然多样性决定细胞毒素活性。
Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.
作者信息
Letley D P, Atherton J C
机构信息
Division of Gastroenterology and Institute of Infections and Immunity, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
出版信息
J Bacteriol. 2000 Jun;182(11):3278-80. doi: 10.1128/JB.182.11.3278-3280.2000.
Abstract
Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.
摘要
与具有细胞毒性的s1型菌株相比，自然存在的无细胞毒性的幽门螺杆菌vacA s2型菌株的空泡毒素（VacA）有一个12个残基的延伸。我们发现，将编码该延伸区域的片段添加到s1型vacA中，会完全消除空泡毒素活性，但对VacA的产生没有影响。
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