Demling R H
Burn Center, Brigham and Women's and Beth Israel Hospitals, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA.
Wound Repair Regen. 2000 Mar-Apr;8(2):97-102. doi: 10.1046/j.1524-475x.2000.00097.x.
The effect of the anabolic steroid oxandrolone on the healing rate of a standardized full thickness linear wound on the back of the rat was studied. Oxandrolone was given orally by gavage in peanut oil at a dose of 0.1 mg/kg/day. A placebo powder in peanut oil was given at the same dose to a control group. Parameters monitored were time to complete wound closure, wound hydroxyproline content and tensile strength, as well as histology. We found that wounds closed completely in 12+/-3 days with oxandrolone, compared to 18+/-3 days for a placebo, a statistically significant difference. The rate of body weight gain was identical in both groups. Hydroxyproline content of the healed incision site was 23+/-4 mg/g tissue vs. 17+/-3 mg/g tissue, while the tensile strength increased to 185+/-13 g/mm2 vs. 102+/-18 g/mm2 in the oxandrolone and placebo groups, respectively. Both parameters were significantly increased with the anabolic steroid. Histologic examination showed a wound that contained more mature and densely packed collagen and was also hypercellular with oxandrolone treatment. We conclude that the anabolic steroid oxandrolone significantly enhanced wound healing unrelated to any generalized increase in protein mass as would be reflected in body weight.
研究了合成代谢类固醇氧雄龙对大鼠背部标准化全层线性伤口愈合速率的影响。氧雄龙以0.1毫克/千克/天的剂量通过灌胃经花生油口服给药。向对照组以相同剂量给予花生油中的安慰剂粉末。监测的参数包括伤口完全闭合的时间、伤口羟脯氨酸含量和抗张强度，以及组织学情况。我们发现，使用氧雄龙的情况下伤口在12±3天完全闭合，而使用安慰剂时为18±3天，差异具有统计学意义。两组的体重增加速率相同。愈合切口部位的羟脯氨酸含量在氧雄龙组和安慰剂组分别为23±4毫克/克组织和17±3毫克/克组织，而抗张强度分别增至185±13克/平方毫米和102±18克/平方毫米。使用合成代谢类固醇后这两个参数均显著增加。组织学检查显示，经氧雄龙治疗的伤口含有更成熟且排列紧密的胶原蛋白，并且细胞增多。我们得出结论，合成代谢类固醇氧雄龙显著促进伤口愈合，这与体重所反映的蛋白质总量的任何普遍增加无关。
