Ramanathan R, Misra U K
Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Jul;28(1):35-43. doi: 10.1080/09553007514550731.
Whole-body gamma-irradiation (1200 R) of female rats significantly increased liver glycogen and incorporation of glucose (U-14C) into liver fatty acids. Administration of cystamine before irradiation protected the enhanced lipogenesis from glucose (U-14C), but afforded only a partial protection of liver glycogen levels. Irradiation significantly decreased the activities of liver pyruvate kinase and isocitrate dehydrogenase, and this decrease was not prevented by the administration of cystamine before irradiation. A significant increase in the activity of liver malate dehydrogenase (dehydrogenating) was noted in irradiated rats, which was not prevented by the administration of cystamine before irradiation. Irradiation did not affect the activities of combined hexose monophosphate pathway dehydrogenases and of malate dehydrogenase (decarboxylating).
对雌性大鼠进行全身γ射线照射（1200拉德）可显著增加肝糖原含量以及葡萄糖（U-14C）掺入肝脏脂肪酸的量。照射前给予半胱胺可保护由葡萄糖（U-14C）增强的脂肪生成，但对肝糖原水平仅提供部分保护。照射显著降低了肝脏丙酮酸激酶和异柠檬酸脱氢酶的活性，且照射前给予半胱胺并不能阻止这种降低。在受照射大鼠中观察到肝脏苹果酸脱氢酶（脱氢）活性显著增加，照射前给予半胱胺也不能阻止这种增加。照射不影响磷酸己糖途径联合脱氢酶和苹果酸脱氢酶（脱羧）的活性。
