Umeda T, Yamamoto T, Kajino K, Hino O
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
Int J Oncol. 2000 Jun;16(6):1133-6. doi: 10.3892/ijo.16.6.1133.
beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes transgenic mice and chemically-induced models. We investigated beta-catenin mutations in human hepatocellular carcinomas (HCCs), Hep G2 cell line and HCCs in SV40 T-antigen transgenic mice, in order to examine whether beta-catenin mutations are frequently observed in HCC in general. We found a point mutation of beta-catenin in one of nine HCCs in human and a deletion of it in Hep G2 cell line. However, we found no mutation in HCC in SV40 TG mice liver.
β-连环蛋白突变不仅在黑色素瘤和前列腺癌中被发现，在人类肝细胞癌、c-myc、H-ras基因转基因小鼠及化学诱导模型中也有发现。我们研究了人类肝细胞癌（HCC）、Hep G2细胞系以及SV40 T抗原转基因小鼠中的HCC中的β-连环蛋白突变情况，以检验β-连环蛋白突变在一般HCC中是否常见。我们在9例人类HCC中的1例中发现了β-连环蛋白的一个点突变，在Hep G2细胞系中发现了它的缺失。然而，我们在SV40 TG小鼠肝脏的HCC中未发现突变。
