肝硬化患者中结核病的发病率及预后。一项基于丹麦全国人口的研究。
Incidence and prognosis of tuberculosis in patients with cirrhosis of the liver. A Danish nationwide population based study.
作者信息
Thulstrup A M, Mølle I, Svendsen N, Sørensen H T
机构信息
Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, Aarhus University, Denmark.
出版信息
Epidemiol Infect. 2000 Apr;124(2):221-5. doi: 10.1017/s0950268899003593.
We examined the incidence rate and prognosis of tuberculosis in a cohort of patients with liver cirrhosis in Denmark. In a study cohort of 22675 patients with liver cirrhosis, we identified 151 cases of tuberculosis from 1977 to 1993. The incidence rate was 168.6 per 100000 person-years of risk, and the highest incidence rate was among men above 65 years of age, with an incidence rate of 246.0 per 100000 person-years of risk. The 30-day case-fatality rate was 27.3% and the 1-year case fatality rate was 47.7%. The results demonstrate that patients with liver cirrhosis are at increased risk of tuberculosis. Additionally, it is suggested that liver cirrhosis is an independent risk factor for tuberculosis, and that patients with liver cirrhosis who acquire tuberculosis have a poor prognosis.
我们调查了丹麦肝硬化患者队列中结核病的发病率和预后情况。在一个由22675名肝硬化患者组成的研究队列中，我们确定了1977年至1993年间的151例结核病病例。发病率为每100000人年风险168.6例，最高发病率出现在65岁以上男性中，每100000人年风险发病率为246.0例。30天病死率为27.3%，1年病死率为47.7%。结果表明，肝硬化患者患结核病的风险增加。此外，提示肝硬化是结核病的一个独立危险因素，肝硬化患者患结核病后预后较差。
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