Bode J, Benham C, Knopp A, Mielke C
GBF, National Center for Biotechnological Research, Braunschweig.
Crit Rev Eukaryot Gene Expr. 2000;10(1):73-90.
For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.
长期以来，基质附着区域（S/MARs）只能通过导致其被检测到的体外实验来表征。直到最近，一些生物学活性才出现，这些活性是大多数或所有通过经典程序检测到的S/MARs所共有的。本综述重点关注基因组锚定基因或游离基因中发现的转录增强现象，以及一组适合维持游离状态的部分重叠活性。此外，还试图将S/MAR-支架相互作用的特性与突出的或原型蛋白结合伴侣联系起来。
