Sahna E, Kurcer Z, Ozturk F, Cengiz N, Vardi N, Birincioglu M, Olmez E
Department of Pharmacology, Faculty of Medicine, In]on]u University, Malatya, 44069, Turkey.
Pharmacol Res. 2000 Jun;41(6):629-33. doi: 10.1006/phrs.1999.0629.
The effects of chronic oral administration of ethanol (7.2% daily during 24 weeks) on the contractions induced by phenylephrine (Phe) and the endothelium-dependent relaxation responses to acetylcholine (ACh) were studied in rat thoracic aorta. Ethanol pretreatment significantly attenuated the contractile responses to Phe, resulting in parallel shift of the concentration-response curve to the right. EC(50)values of Phe were 64.6+/-11.2 and 95.5+/-8.5 nmol l(-1)in control and ethanol-fed rats, respectively. On the other hand, either calcium-induced contractions or relaxation responses to ACh and sodium nitroprusside were similar in the vessels of the control and ethanol-treated rats. These results suggest that chronic ethanol ingestion significantly attenuates the alpha(1)-adrenergic-induced contractions but does not affect the relaxation responses mediated by nitric oxide in rat aortic rings.
研究了大鼠胸主动脉中慢性口服乙醇（24周内每日7.2%）对去氧肾上腺素（Phe）诱导的收缩以及对乙酰胆碱（ACh）的内皮依赖性舒张反应的影响。乙醇预处理显著减弱了对Phe的收缩反应，导致浓度-反应曲线平行右移。对照组和乙醇喂养组大鼠中Phe的半数有效浓度（EC50）值分别为64.6±11.2和95.5±8.5 nmol l(-1)。另一方面，对照组和乙醇处理组大鼠血管中钙诱导的收缩或对ACh和硝普钠的舒张反应相似。这些结果表明，长期摄入乙醇可显著减弱α(1)-肾上腺素能诱导的收缩，但不影响大鼠主动脉环中一氧化氮介导的舒张反应。
