Soler C P, Gerome P, Leguyadec T, Hance P, Nizou J Y, Le Vagueresse R
Service de Biologie Médicale, l'Hôpital d'Instruction des Armées Percy, Clamart, France.
Med Trop (Mars). 1999;59(4):375-7.
Scytalidium dimidiatum is a fungus found mainly in tropical and subtropical zones. Infection can cause a benign disease closely resembling dermatophytosis. In immunocompromised hosts, Scytalidium dimidiatum can also lead to phaehyphomycosis. Although awareness of these hyphae remains limited in developed countries, their incidence is growing due to increasing immigration and tourism. The rising incidence is well illustrated by three patients who presented onyxis and squamous-like manifestations on the arch of the foot upon returning from trips overseas and in whom various treatments were unsuccessful. In all three cases, culture in non-selective Sabouraud medium identified Scytalidium dimidiatum. These findings underline the need for laboratory testing before undertaking local or systemic treatment of onyxis especially since this pathogen can cause systemic disease. Study of ribosome genes showed that Scytalidium hyalinum is an homologous unpigmented mutant form of Scytalidium dimidatum. No antifungal agent has been effective for management of superficial manifestations and prevention depends mainly on the use of appropriate footwear in endemic areas.
暗孢节菱孢是一种主要发现于热带和亚热带地区的真菌。感染可引起一种与皮肤癣菌病极为相似的良性疾病。在免疫功能低下的宿主中，暗孢节菱孢还可导致暗色丝孢霉病。尽管在发达国家对这些菌丝的认知仍然有限，但由于移民和旅游业的增加，其发病率正在上升。三名患者从海外旅行归来后，足部足弓出现甲癣和鳞状样表现，且各种治疗均未成功，这很好地说明了发病率的上升。在所有三例病例中，在非选择性沙氏培养基上培养鉴定出了暗孢节菱孢。这些发现强调了在对甲癣进行局部或全身治疗之前进行实验室检测的必要性，特别是因为这种病原体可引起全身性疾病。核糖体基因研究表明，透明节菱孢是暗孢节菱孢的一种同源无色素突变形式。尚无抗真菌药物对浅表表现的治疗有效，预防主要依赖于在流行地区使用合适的鞋类。
