Pagès G, Girard A, Jeanneton O, Barbe P, Wolf C, Lafontan M, Valet P, Saulnier-Blache J S
INSERM U317, Institut Louis Bugnard, Université Paul Sabatier, CHU Rangueil, Toulouse, France.
Ann N Y Acad Sci. 2000 Apr;905:159-64. doi: 10.1111/j.1749-6632.2000.tb06547.x.
Adipogenesis corresponds to the recruitment of new adipocytes in adipose tissue, and results from the proliferation/differentiation of preadipocytes. Production of paracrine and autocrine factors by adipocytes plays an important role in adipogenesis. We recently demonstrated the existence of adipocyte production of lysophosphatidic acid (LPA) both in vitro and in situ. This production is modulated by catecholamines via alpha 2-adrenergic receptors. Adipocyte-LPA present in conditioned media increases the growth of a preadipose cell line in culture. This growth is associated with an activation of mitogen-activated protein kinases, and of the focal adhesion kinase. Because of the close proximity of preadipocytes and adipocytes within adipose tissue, adipocyte-LPA could play an important role in autocrine/paracrine control of adipogenesis.
脂肪生成对应于脂肪组织中新脂肪细胞的募集，由前脂肪细胞的增殖/分化产生。脂肪细胞产生的旁分泌和自分泌因子在脂肪生成中起重要作用。我们最近证明了在体外和原位脂肪细胞均可产生溶血磷脂酸（LPA）。这种产生受儿茶酚胺通过α2 - 肾上腺素能受体调节。条件培养基中的脂肪细胞源性LPA可增加培养的前脂肪细胞系的生长。这种生长与丝裂原活化蛋白激酶和粘着斑激酶的激活有关。由于脂肪组织中前脂肪细胞和脂肪细胞紧密相邻，脂肪细胞源性LPA可能在脂肪生成的自分泌/旁分泌控制中起重要作用。
