Glode M P, Schiffer M S, Robbins J B, Khan W, Battle C U, Armenta E
J Pediatr. 1976 Jan;88(1):36-40. doi: 10.1016/s0022-3476(76)80723-8.
Five cases of HITB maningitis occurred within six months in an enclosed population of 28 to 32 chronically ill children. Studies of nasopharyngeal carriage and serum HITB anticapsular antibodies were started after the third case occurred. Two patients had low (less than 0.04 and 0.05mug/ml) antibodies and were not carriers when studied prior to onset of their disease. The carriage rate was approximately 20% among the children. Carriage was usually prolonged, and acquisition was not prevented by high antibody levels. Attempts to arrest this outbreak with type b polysaccharide immunization and ampicillin therapy are discussed in the context of HITB meningitis as a contagious disease.
在一个由28至32名慢性病患儿组成的封闭群体中，6个月内发生了5例b型流感嗜血杆菌脑膜炎。在第3例病例出现后，开始了对鼻咽部带菌情况和血清b型流感嗜血杆菌抗荚膜抗体的研究。两名患者抗体水平较低（分别低于0.04和0.05微克/毫升），在发病前进行研究时并非带菌者。儿童中的带菌率约为20%。带菌情况通常持续时间较长，高抗体水平并不能预防感染。本文结合b型流感嗜血杆菌脑膜炎作为一种传染病的情况，讨论了使用b型多糖免疫和氨苄西林治疗来控制此次疫情的尝试。
