Puzianowska-Kuznicka M, Nauman A, Madej A, Tanski Z, Cheng S, Nauman J
Department of Endocrinology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland.
Cancer Lett. 2000 Jul 31;155(2):145-52. doi: 10.1016/s0304-3835(00)00416-x.
Human renal clear cell carcinoma (RCCC) accounts for up to 2% of human cancers. To find out if thyroid hormone (T3) and its receptors (TRs) play a role in tumorigenesis of RCCC, the expression of TRs was evaluated on mRNA and protein level. It was found that TRalpha (both alpha1 and alpha2) mRNA amount was significantly decreased in tumors while compared with healthy kidney tissue, and this decrease was deepest in G1 (well differentiated) RCCCs. In contrast, TRalpha1 protein was 1.6x overexpressed in tumors. TRbeta1 mRNA amount was overexpressed in 30% and significantly decreased in 70% of examined tumors. On the protein level, TRbeta1 amount was 1.7x lower in tumors than in healthy controls.
人类肾透明细胞癌（RCCC）占人类癌症的比例高达2%。为了探究甲状腺激素（T3）及其受体（TRs）是否在RCCC的肿瘤发生中起作用，我们在mRNA和蛋白质水平上评估了TRs的表达。结果发现，与健康肾组织相比，肿瘤中TRα（α1和α2）的mRNA量显著降低，且这种降低在G1期（高分化）RCCC中最为明显。相反，TRα1蛋白在肿瘤中过表达1.6倍。TRβ1的mRNA量在30%的检测肿瘤中过表达，在70%的肿瘤中显著降低。在蛋白质水平上，肿瘤中的TRβ1量比健康对照低1.7倍。
