Sorensen K N, Clemons K V, Stevens D A
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA.
Mycopathologia. 1999;146(2):53-65. doi: 10.1023/a:1007081707287.
Animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. This is true for animal models of the primary fungal pathogens, Blastomyces dermatitidis, Coccidioides immitis, and Histoplasma capsulatum. This review gives a brief background of human diseases associated with these organisms and describes the development, details, and utility of murine models of blastomycosis, as well as coccidioidomycosis and histoplasmosis.
动物模型对真菌感染及其相应治疗方法的了解贡献巨大。对于原发性真菌病原体皮炎芽生菌、粗球孢子菌和荚膜组织胞浆菌的动物模型来说也是如此。本综述简要介绍了与这些生物体相关的人类疾病背景,并描述了芽生菌病、球孢子菌病和组织胞浆菌病小鼠模型的发展、细节和用途。