Shvets-Ténéta-Guriĭ T B, Troshin G I, Dubinin A G, Novikova M R
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2000 Mar-Apr;50(2):261-73.
Variations of the brain cortex redox state potential (E) were recorded in freely moving white rats (mass of 300-350 g) with implanted platinum electrodes (with the platinum reference electrode in the nasal bone) during sleep-wake cycles. It was found that transitions from the slow-wave sleep to wakefulness were accompanied in the number of cortical areas (metabolic-active sites) by the E rise, while the transitions from the wakefulness to slow-ware sleep were associated with a drop of E. However, the episodes of the short-term arousals during the slow-wave sleep were accompanied by the respective decreases in E thus forming the irregular E variations (1.5-3 min in duration). It was also found that the oscillations of a typical pattern (quasisinusoidal with the frequency of 10-20 osc/min and the amplitudes up to several mV) could take place in the metabolic-active cortical sites. These oscillations were defined as fast E oscillations. During the slow-wave sleep, the less regular oscillations with the lower frequency (1.2-10 osc/min) and higher amplitude were recorded in the same cortical sites. These oscillations were defined as slow. It is suggested that the fast metabolic oscillations of wakefulness are mainly controlled by the mitochondria of neuronal populations, whereas the slow metabolic oscillations which occur in the slow-wave sleep are related with glycolysis in populations of glial cells.
在睡眠-觉醒周期中，使用植入的铂电极（铂参比电极置于鼻骨），对自由活动的体重300 - 350克的白鼠大脑皮层氧化还原状态电位（E）的变化进行了记录。结果发现，从慢波睡眠向觉醒转变时，皮层区域（代谢活跃位点）数量伴随着E值升高，而从觉醒向慢波睡眠转变则与E值下降相关。然而，慢波睡眠期间的短期觉醒发作伴随着E值相应下降，从而形成持续时间为1.5 - 3分钟的不规则E值变化。还发现，在代谢活跃的皮层位点可出现典型模式的振荡（频率为10 - 20次/分钟、振幅高达数毫伏的准正弦振荡）。这些振荡被定义为快速E振荡。在慢波睡眠期间，在相同皮层位点记录到频率较低（1.2 - 10次/分钟）、振幅较高且不太规则的振荡。这些振荡被定义为慢速振荡。研究表明，觉醒时的快速代谢振荡主要由神经元群体的线粒体控制，而慢波睡眠中出现的慢速代谢振荡与胶质细胞群体的糖酵解有关。
