单纯疱疹病毒1型复制起点（Ori(S)）被病毒起点结合蛋白和单链DNA结合蛋白复合物解开。
Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.
作者信息
He X, Lehman I R
机构信息
Department of Biochemistry, Stanford University, Stanford, California 94305-5037, USA.
出版信息
J Virol. 2000 Jun;74(12):5726-8. doi: 10.1128/jvi.74.12.5726-5728.2000.
Abstract
A herpes simplex virus type 1 (HSV-1) Ori(S) analogue in which the A+T sequence linking the box I and II elements was replaced by two single-stranded oligo(dT)s is unwound by the UL9 protein-ICP8 complex. Unwinding of wild-type Ori(S) by the UL9 protein-ICP8 complex was also observed under conditions which destabilize the A+T sequence. These experiments support a model for the unwinding of Ori(S) in which destabilization of the A+T sequence can generate a single-stranded DNA binding site for ICP8, which then associates with the UL9 protein bound to boxes I and II to promote the bidirectional unwinding of Ori(S).
摘要
一种1型单纯疱疹病毒（HSV-1）的Ori(S)类似物，其中连接框I和框II元件的A+T序列被两条单链寡聚（dT）取代，该类似物被UL9蛋白-ICP8复合物解开。在使A+T序列不稳定的条件下，也观察到UL9蛋白-ICP8复合物对野生型Ori(S)的解旋。这些实验支持了一种Ori(S)解旋模型，其中A+T序列的不稳定可产生一个ICP8的单链DNA结合位点，然后该位点与结合在框I和框II上的UL9蛋白结合，以促进Ori(S)的双向解旋。
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