单纯疱疹病毒1型基因组中包含DNA聚合酶基因和主要DNA结合蛋白基因的区域的DNA序列。
DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein.
作者信息
Quinn J P, McGeoch D J
出版信息
Nucleic Acids Res. 1985 Nov 25;13(22):8143-63. doi: 10.1093/nar/13.22.8143.
Abstract
In the long unique region of the genome of herpes simplex virus type 1 (HSV-1), the genes for DNA polymerase and the major DNA binding protein are arranged in a head to head manner, with an origin of DNA replication (termed OriL) located between them. This paper reports an 8400 base pair DNA sequence containing both genes and the origin, obtained mostly by M13/dideoxy analysis of plasmid cloned fragments. Amino acid sequences of the two proteins were deduced. Homologues of both genes were detected in the genome sequence of the distantly related Epstein-Barr virus (EBV). Arrangement of these HSV-1 and EBV genes differs in genome location and in relative orientation. A part of HSV-1 DNA polymerase was found to be similar to a sequence in adenovirus 2 DNA polymerase, but the significance of this is unclear. Since a DNA sequence in the locality of OriL deletes on plasmid cloning, this region was analysed using virus DNA. A palindrome with 72-residue arms was found, which shows great similarity to the better characterized origin, OriS.
摘要
在单纯疱疹病毒1型（HSV-1）基因组的长独特区域中，DNA聚合酶基因和主要DNA结合蛋白基因以头对头的方式排列，它们之间有一个DNA复制起点（称为OriL）。本文报道了一段包含这两个基因及起点的8400碱基对的DNA序列，该序列主要通过对质粒克隆片段的M13/双脱氧分析获得。推导了这两种蛋白质的氨基酸序列。在远缘的爱泼斯坦-巴尔病毒（EBV）基因组序列中检测到了这两个基因的同源物。HSV-1和EBV这些基因的排列在基因组位置和相对方向上有所不同。发现HSV-1 DNA聚合酶的一部分与腺病毒2 DNA聚合酶中的一个序列相似，但其意义尚不清楚。由于OriL所在区域在质粒克隆时会缺失，因此使用病毒DNA对该区域进行了分析。发现了一个具有72个残基臂的回文结构，它与特征更明确的起点OriS非常相似。
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