甲状腺胃自身免疫性疾病。关于细胞介导免疫系统和组织相容性抗原的研究。
Thyrogastric autoimmune disease. Studies on the cell-mediated immune system and histocompatibility antigens.
作者信息
Whittingham S, Youngchaiyud U, Mackay I R, Buckley J D, Morris P J
出版信息
Clin Exp Immunol. 1975 Feb;19(2):289-99.
Cell-mediated immune responses were studied in autoimmune diseases of thyrogastric type, Hashimoto's thyroiditis and autoimmune pernicious anaemia-type gastritis. Specific cell-mediated immunity was investigated by the leucocyte migration inhibition procedure, and general cell-mediated immunity (T-cell performance) was studied by standard in vivo and in vitro tests. In thyrogastric autoimmune diseases inhibition of migration of leucocytes was induced by thyroglobulin and gastric parietal cell microsomes; under conditions of presumably low cellular sensitization, stimulation of migration was observed. There was no depression of general cell-mediated immunity, in contrast to what occurs in systemic lupus erythematosus and related autoimmune diseases. A weak association of autoimmune gastritis with HL-A3 and HL-A7 (P LESS THAN 0.05) lost significance when an appropriate correction was applied; this weakness with HL-A clearly does not explain the strong genetic component in thyroid and gastric autoimmunity.
在甲状腺胃型自身免疫性疾病、桥本甲状腺炎和自身免疫性恶性贫血型胃炎中研究了细胞介导的免疫反应。通过白细胞迁移抑制试验研究特异性细胞介导的免疫，通过标准的体内和体外试验研究一般细胞介导的免疫（T细胞功能）。在甲状腺胃自身免疫性疾病中，甲状腺球蛋白和胃壁细胞微粒体可诱导白细胞迁移受到抑制；在假定细胞致敏性较低的情况下，观察到迁移受到刺激。与系统性红斑狼疮及相关自身免疫性疾病不同，一般细胞介导的免疫并未受到抑制。自身免疫性胃炎与HL-A3和HL-A7存在弱关联（P小于0.05），但在进行适当校正后这种关联失去了显著性；与HL-A的这种微弱关联显然无法解释甲状腺和胃自身免疫中强大的遗传成分。
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