In search of gamma-secretase: presenilin at the cutting edge.
作者信息
Selkoe D J, Wolfe M S
机构信息
Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2. doi: 10.1073/pnas.97.11.5690.
Abstract
摘要
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Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2. doi: 10.1073/pnas.97.11.5690.
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本文引用的文献
1
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.Notch信号通路中涉及的一种新型蛋白水解切割：解整合素金属蛋白酶TACE的作用。
Mol Cell. 2000 Feb;5(2):207-16. doi: 10.1016/s1097-2765(00)80417-7.
2
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.配体诱导的细胞外切割调节Notch1的γ-分泌酶样蛋白水解激活。
Mol Cell. 2000 Feb;5(2):197-206. doi: 10.1016/s1097-2765(00)80416-5.
3
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.早老素1在去污剂溶解状态下与γ-分泌酶活性相关。
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. doi: 10.1073/pnas.110126897.
4
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.调节性膜内蛋白水解：一种从细菌到人类都保守的控制机制。
Cell. 2000 Feb 18;100(4):391-8. doi: 10.1016/s0092-8674(00)80675-3.
5
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.人天冬氨酸蛋白酶膜内天冬氨酸蛋白酶2切割β-淀粉样前体蛋白的β-分泌酶位点。
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. doi: 10.1073/pnas.97.4.1456.
6
Identification of a novel aspartic protease (Asp 2) as beta-secretase.鉴定一种新型天冬氨酸蛋白酶（Asp 2）作为β-分泌酶。
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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.细胞表面早老素-1参与Notch的γ-分泌酶样蛋白水解过程。
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9
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