Weber U, Schmid H
Hoppe Seylers Z Physiol Chem. 1975 Oct;356(10):1505-15.
The synthesis of the following 3 model peptides from the active center of the inhibitor molecule is described: (see article). The 3 peptides are split by trypsin with velocities increasing from (I) to (III). The following Ki values were determined: (I) Ki = 2.3 x 10(-2)M; (II) Ki = 4.9 x 10(-3)M; (III) Ki = 2.1 x 10(-3)M. These Ki values differ from the Ki values of the Kunitz inhibitor by a factor 10(11) to 10(12).
文中描述了从抑制剂分子活性中心合成以下3种模型肽的过程：（见文章）。这3种肽被胰蛋白酶切割，切割速度从（I）到（III）逐渐增加。测定了以下Ki值：（I）Ki = 2.3×10⁻²M；（II）Ki = 4.9×10⁻³M；（III）Ki = 2.1×10⁻³M。这些Ki值与库尼茨抑制剂的Ki值相差10¹¹到10¹²倍。
