Jin Z H, Kumakiri M, Ishida H, Kinebuchi S
Department of Dermatology, Fukui Medical University, Japan.
J Dermatol. 2000 Apr;27(4):233-7. doi: 10.1111/j.1346-8138.2000.tb02157.x.
Combined nevi consisting of a Spitz nevus and an acquired nevus are unusual, and, to our knowledge, the combination of a spindle cell Spitz nevus and an overlying compound nevus has not been previously reported. We report a 17-year-old girl with a nodule on the left anterior lower extremity. The nodule was asymptomatic, firm, brown, symmetrical, dome-shaped, 8 mm in diameter, and not found with ulceration. Histological findings showed proliferation of spindle-shaped cells with an overlying compound nevus. The spindle-shaped cells were large, non-pigmented, uniform in size and shape, with rare mitoses and without nuclear atypia, and arranged in a storiform pattern in thick collagen bundles. They stained positively for S-100 and negatively for HMB-45. The lesion was considered to be a new type of combined nevus consisting of a spindle cell Spitz nevus and an overlying compound nevus.
由Spitz痣和后天性痣组成的复合痣并不常见，据我们所知，梭形细胞Spitz痣与上方复合痣的组合此前尚未见报道。我们报告了一名17岁女性，其左下肢前侧有一个结节。该结节无症状，质地硬，呈褐色，对称，圆顶状，直径8毫米，未发现溃疡。组织学检查结果显示梭形细胞增生，上方有复合痣。梭形细胞大，无色素，大小和形状均匀，有罕见的有丝分裂且无核异型性，在厚胶原束中呈束状排列。它们S-100染色阳性，HMB-45染色阴性。该病变被认为是一种由梭形细胞Spitz痣和上方复合痣组成的新型复合痣。
