Debby A, Golan A, Sadan O, Zakut H, Glezerman M
Department of Obstetrics and Gynaecology, The Edith Wolfson Medical Center, Holon and Sackler Medical School, Tel Aviv, Israel.
BJOG. 2000 May;107(5):626-30. doi: 10.1111/j.1471-0528.2000.tb13304.x.
To assess the effectiveness of systemic treatment with methotrexate in combination with local injection for unruptured tubal pregnancy, and to evaluate reproductive function following treatment.
Prospective, open clinical study.
University clinic.
Sixty-seven women with unruptured tubal pregnancy.
Systemic methotrexate (intramuscular methotrexate 0.5 mg/kg for up to five days) in combination with local application of 12.5 mg methotrexate via laparoscopy.
The subsequent surgical intervention required and future fertility.
In 89.6% of women no further surgical intervention was required and 47 women (81%) experienced subsequently an intrauterine pregnancy. In 39 of 40 women who underwent hysterosalpingography following treatment, patency of the affected tube was observed.
Combined local and systemic methotrexate treatment for unruptured tubal pregnancy seems to be more effective than each therapeutic modality alone.
评估甲氨蝶呤全身治疗联合局部注射治疗未破裂输卵管妊娠的有效性，并评估治疗后的生殖功能。
前瞻性、开放性临床研究。
大学诊所。
67例未破裂输卵管妊娠的女性。
全身应用甲氨蝶呤（肌内注射甲氨蝶呤0.5mg/kg，最多5天）联合腹腔镜局部应用12.5mg甲氨蝶呤。
后续所需的手术干预和未来生育能力。
89.6%的女性无需进一步手术干预，47名女性（81%）随后发生宫内妊娠。在40例治疗后接受子宫输卵管造影的女性中，有39例观察到患侧输卵管通畅。
甲氨蝶呤局部与全身联合治疗未破裂输卵管妊娠似乎比单独使用每种治疗方式更有效。
