Soares J C, Gershon S
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pa, USA.
J Clin Psychiatry. 2000;61 Suppl 9:16-22.
This article examines the development of lithium therapy since its dramatic introduction into psychiatry in 1949. Since that time, lithium has been examined in the treatment of a variety of neuropsychiatric conditions, but it is in the treatment of bipolar disorder that it is most effective. This suggests that it has specificity in the treatment of this disorder. These findings are very relevant as they suggest that understanding the mechanism of action of lithium in bipolar disorder may hold keys to elucidating its pathophysiology and to developing newer and more effective treatments. We review the published data on the effectiveness of lithium in bipolar disorder and various neuropsychiatric conditions and also the available data on anticonvulsants and newer therapeutic agents in the treatment of this condition.
本文探讨了自1949年锂疗法戏剧性地引入精神病学领域以来的发展历程。自那时起，锂已被用于多种神经精神疾病的治疗，但在双相情感障碍的治疗中最为有效。这表明它在治疗这种疾病方面具有特异性。这些发现非常重要，因为它们表明了解锂在双相情感障碍中的作用机制可能是阐明其病理生理学以及开发更新、更有效治疗方法的关键。我们回顾了已发表的关于锂在双相情感障碍及各种神经精神疾病中的疗效数据，以及抗惊厥药和新型治疗药物在治疗该疾病方面的现有数据。
